Once a daily proto-type gastro retentive dosage forms of Metoprolol tartrate (MT); �Ÿ1-selective adrenergic blocking agent was developed to increase the gastric retention, extend the drug release and to improve its oral bioavailability. Gastro retentive dosage forms (GRDF) were formulated using Hydroxy Propyl Methyl Cellulose (HPMC K100M) a synthetic polymer and Xanthan gum (XG) a natural polymer as drug release retardant and NaHCO3 as gas generating agent. The tablets were prepared by direct compression method and evaluated for various physico-chemical/mechanical parameters. Based on drug release kinetics, it can be concluded that the floating tablet containing 35%w/w HPMC K100M as the release retardant, Micro crystalline cellulose (Avicel PH 101) as filler and 20%w/w NaHCO3 as gas generating agent was a particularly suitable gastro retentive drug delivery system with a first order release profile.
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